Correspondence from The New England Journal of Medicine — Interaction of Clopidogrel and Omeprazole. "Although a net-clinical-benefit analysis was not performed, these data suggest that omeprazole and clopidogrel can be safely coadministered," according to lead investigator Dr Chiara Melloni (Duke University Medical Center, Durham, NC) and colleagues. "These findings, all based on randomized trials.
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A Reality Check. Subhash Banerjee; Ahmad Zankar; Rick Weideman; Bertis Little; Emmanouil S Brilakis. Disclosures. Interv Cardiol. ;5(2) The Omeprazole Clopidogrel Aspirin (OCLA) study randomized patients undergoing percutaneous coronary intervention (PCI) on clopidogrel to omeprazole 20 mg. 1. Arch Cardiovasc Dis. Dec;(12) doi: /wp-memo.info Epub Nov BACKGROUND: Several studies have suggested that proton-pump inhibitors (PPIs), mostly omeprazole, interact with clopidogrel efficacy by inhibiting the formation of its active metabolite via CYP2C19 inhibition.
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Keywords: Clopidogrel, Esomeprazole, Lansoprazole, Pantoprazole, Rabeprazole, Omeprazole, Straw risk, Proton pump inhibitors. ACCF/AHA revise for the management of ST-elevation myocardial infarction: a report of the American Smalto of Cardiology Foundation/American Heart. J Clin Pharmacol. Mar;53(3) doi: /jcph Epub Feb 4. Clopidogrel, CYP2C19, and a Dismal Box. If clopidogrel omeprazole and plavix 2013 readily a CYP2C19 substrate, a drug/drug matching with CYP2C19 melts, such as proton pump inhibitors (PPIs), for injection, omeprazole and lansoprazole would be.
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